Green dissolution: pioneering sustainable practices in pharmaceutical testing

Prasanta Kumar  Choudhury; Gourishyam  Pasa; Rajeshree  Panigrahi

doi:10.69857/joapt.v1i1.10

Authors

Prasanta Kumar Choudhury Department of Pharmaceutics, Royal College of Pharmacy and Health Science, Andhapasara Road, Berhampur - 760002, Dist. Ganjam, Odisha
Gourishyam Pasa Department of Pharmaceutics, Royal College of Pharmacy and Health Science, Andhapasara Road, Berhampur - 760002, Dist. Ganjam, Odisha, India
Rajeshree Panigrahi Department of Pharmaceutics, Royal College of Pharmacy and Health Science, Andhapasara Road, Berhampur - 760002, Dist. Ganjam, Odisha

DOI:

https://doi.org/10.69857/joapt.v1i1.10

Keywords:

Sustainable Pharmaceuticals, Green Dissolution Media, Biorelevant Testing, Miniaturized Dissolution Systems, Environmental Impact Minimization

Abstract

Background: Green dissolution is a pharmaceutical testing method that addresses environmental concerns without compromising scientific accuracy. The objective of this work is to survey and discuss new technologies and approaches to minimize the ecological impact of dissolution testing in drug development and quality control. Methodology: The review focuses on key areas of green dissolution, including environmentally friendly dissolution media, eco-friendly excipients, and energy-efficient operations. Examples of state-of-the-art technologies include biorelevant media, miniaturization, 3D printing, and green analytical methods. Results: The review identifies successful implementations of green dissolution practices in formulation development, quality control, and bioequivalence studies, suggesting that they can have far-reaching effects in the pharmaceutical field. Discussion: Although regulatory approval will be difficult and start-up costs may be high, there is significant potential to increase efficiency and reduce the environmental footprint. Future trends include AI-assisted modelling, zero-waste, and industry-level standardization. Conclusion: These sustainable practices will become the new norm in pharmaceutical testing by aligning with green chemistry principles and will help not only preserve the environment but also improve drug development outcomes.

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